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In Florida, the estimated annual economic impacts from HABs are in the magnitude of millions of dollars with direct effects to both tourism and public health. The subtropical warm climate, 1200 miles of coastline, varied aquatic habitats and the human interface through seafood consumption and from water activities compose an environment where the presence of aquatic toxins can have a significant impact on public health. Harmful Algal Blooms (HABs) occur throughout the world with Florida having the distinction of being home to all major toxin-producing marine, estuarine and freshwater microalgae.